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In 1861, he developed the ammonia-soda process for the manufacture of soda ash (anhydrous sodium carbonate, a rare chemical called natrite, to distinguish it from natural natron of antiquity) from brine wells dug in the southern end of Tully valley (as a source of sodium chloride) and limestone (as a source of calcium carbonate).

The process was an improvement over the earlier Leblanc process.

In 2010, Forbes rated Syracuse fourth in the top 10 places in the U. At the invitation of the Onondaga Nation, one of the five constituent members of the Iroquois confederacy, a group of Jesuit priests, soldiers, and coureurs des bois (including Pierre Esprit Radisson) set up a mission, known as Sainte Marie among the Iroquois, or Ste.

Marie de Gannentaha, on the northeast shore of Onondaga Lake.

The city has many neighborhoods which were originally various villages that joined the city over the years.

Although the central part of Syracuse is flat, many of its neighborhoods are located on small hills such as University Hill and Tipperary Hill.

The manufacturing industry in Syracuse began to falter in the 1970s.

Today, Syracuse is located at the intersection of Interstates 81 and 90, and its airport is the largest in the region.

Syracuse is home to Syracuse University, a major research university, as well as Le Moyne College, a nationally recognized liberal arts college. The Syracuse area was first seen by Europeans when French missionaries came to the area in the 1600s.

The Syracuse Solvay plant was the incubator for a large chemical industry complex owned by Allied Signal in Syracuse, the result of which made Onondaga Lake the most polluted in the nation.

The salt industry declined after the Civil War, but a new manufacturing industry arose in its place.

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